Diode Laser Irradiation Effects on Miniscrew Stability and IL-1ß and TGF-ß1 Levels: A Split-Mouth Randomized Controlled Clinical Trial.

Introduction: This study aimed to assess the effect of low-level laser therapy (LLLT) on miniscrew stability and concentrations of interleukin-1ß (IL-1ß) and transforming growth factor-beta (TGF-ß1) in peri-miniscrew crevicular fluid in the course of orthodontic treatment. Methods: This randomized split-mouth double-blind clinical trial evaluated 18 patients requiring anterior retraction along with maximum anchorage. Miniscrews were placed between the maxillary second premolar and first molar. A diode laser was irradiated with a 980-nm wavelength and 100-mW output power in continuous-wave mode at four time points: T0 (1 hour after miniscrew placement), T1 (1 week later), T2 (at 1 month) and T3 (at 3 months) in one quadrant of the maxilla (laser group). The other quadrant of the maxilla underwent the pseudo-application of the laser (control group). The primary stability of miniscrews was measured by Periotest M and reported as Periotest value (PTV). Also, at each time point, samples were collected from the peri-miniscrew crevicular fluid one hour after laser irradiation to assess the concentration of IL-1ß and TGF-ß1. Results: The mean PTV (inverse of the stability) was smaller in the laser group compared with the control group at all time points; this difference was significant at T2 and T3. The mean concentration of IL-1ß in the laser group was lower than that in the control group at all time points, and this difference was significantly remarkable at T0 and T3. The mean concentration of TGF-ß1 in the laser group was lower than that in the control group at T0, T1 and T3; however, the difference was not statistically significant. Conclusion: The current results supported the efficacy of LLLT in increasing the miniscrew stability and decreasing the level of IL-1ß pro-inflammatory cytokine.

In vitro comparison of the tensile strength of elastomeric ligatures exposed to Povidone Iodine 1%, Chlorhexidine 0.02%, and hydrogen peroxide 5.

OBJECTIVE: In orthodontic patients using any chemical substances in oral environment could change the elastomeric properties of their appliances. Since the beginning of the SARS-CoV-2 pandemic, efforts have been devoted to explore methods of prevention including the use of antiviral mouthwashes. This study aimed to investigate the effects of Povidone Iodine (PVP-I) and two other disinfecting solutions on the mechanical properties of orthodontic elastomeric ligatures. MATERIALS AND METHODS: In this study, 130 elastomeric ligatures in five groups (three test groups and two control groups) were examined in laboratory conditions for a period of 28 days. In the control group, specimens were kept dry in a dark environment while all other ligatures were stored in artificial saliva. Elastomeric ligatures were immersed into PVP-I solution (1%) Chlorhexidine (0.02%), and hydrogen peroxide (5%) for one minute each day in three time intervals of one day, 7 days and 28 days. Next, the maximum tensile strength of elastomeric ligatures was tested by a universal testing machine (CN 1174, Germany). RESULTS: The results showed that the tensile strength of elastomeric ligatures was significantly decreased in all three test groups after 28 days (p-value<0.05). However, the difference between groups was not statistically significant. Between-subject ANOVA test showed that there were significant correlations between the time of exposure and type of disinfecting solutions. CONCLUSIONS: PVP-I has comparable effects on elastomeric ligatures as artificial saliva, chlorhexidine, and hydrogen peroxide.

A rare case of bilateral double incisors; Early orthodontic management.

A safe and suitable approach in the treatment of unusual malformed anterior maxillary teeth would be to accept a birooted fused incisor as two central teeth by moving it across the midpalatal suture and improve the frontal esthetics.

Hydrodissection: A Novel Approach for Safe Core Needle Biopsy of Small High-Risk Subcapsular Thyroid Nodules.

PURPOSE: To evaluate the safety and effectiveness of core needle biopsy (CNB) under the assistance of hydrodissection (HDS). MATERIALS AND METHODS: Of 2325 patients requiring biopsy of thyroid lesions, 21 high-risk patients with subcapsular nodules smaller than 10 mm were recruited into this study. All patients underwent HDS with 0.9% saline solution followed by ultrasound (US)-guided CNB with an 18-gauge semi-automated biopsy needle. The separation success rate (SSR) of the HDS, technical success rate (TSR) of CNB, histopathologic success rate (HSR), and complications were assessed. RESULTS: Both the SSR of HDS and TSR of CNB were 100% (21/21). The HSR of the thyroid nodules was 85.7% (18/21). No major complications were recorded. CONCLUSION: HDS before CNB can successfully lead to safe biopsy of small subcapsular thyroid nodules. LEVEL OF EVIDENCE: Level 4, Case Series.

Comparative study of 0.2% and 0.12% digluconate chlorhexidine mouth rinses on the level of dental staining and gingival indices.

BACKGROUND: Chlorhexidine (CHX) as a gold standard chemical agent appears to be the most effective antimicrobial agent for reduction of both plaque and gingivitis. The aim of this study was to compare the efficacy of two concentrations of digluconate chlorhexidine (CHX) solutions (0.12% and 0.20%) on gingival indices and the level of dental staining during 14 days. MATERIALS AND METHODS: in this double-blind controlled clinical trial study 60 patients with moderate to severe gingivitis aged 17-56 years were randomly selected and divided to three groups: Group I (placebo) Group II (0.12% CHX), and Group III (0.2% CHX). Patients rinsed their mouthwashes twice a day after brushing. Before the examination and after 14 days plaque index, gingival index, bleeding index, and stain index were evaluated. The data were analyzed by "Mann-Whitney" test and P value was 0.05. RESULTS: the results showed that plaque index and gingival index significantly reduced in Groups II and III in comparison with the placebo group (P < 0.0001). However, the two concentrations did not differ significantly from each other (P = 0.552). Same results were observed in term of gingival bleeding index with this different that 0.2% CHX was significantly more efficient than 0.12% CHX (P < 0.0001). CHX mouthrinse, both concentrations, significantly increased the dental staining level (intensity and area) in comparison with the placebo group. Remarkable difference also was seen between 2 CHX concentrations so that the 0.2% CHX caused much more staining on the teeth than 0.12% CHX. CONCLUSION: based on the results of this study we can conclude that the lower concentrations of CHX should be prescribed, decreasing side effects, since higher concentrations do not seem to be more effective in controlling dental plaque and gingivitis.